HAZMAT is an acronym for Hazardous Materials or safety programs designed to protect the public from exposure to hazardous materials. Various federal agencies have developed regulations for the transportation and disposal of hazardous materials, including the Department of Transportation (DOT), the Environmental Protection Agency (EPA), and the Occupational Safety and Health Administration (OSHA). The exact definition of hazardous materials depends on the regulatory body. Truck drivers, contractors, and other organizations must follow specific regulations regarding the use, transport, and disposal of hazardous materials.